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Effects of valsartan on mechanical properties of the carotid artery in spontaneously hypertensive rats under high-salt diet.
- Source :
-
Hypertension (Dallas, Tex. : 1979) [Hypertension] 2001 Sep; Vol. 38 (3), pp. 439-43. - Publication Year :
- 2001
-
Abstract
- The aim of this investigation was to evaluate the influence of a high-salt diet (HSD) on the effects of valsartan, an angiotensin II type 1 (AT(1)) receptor antagonist, on carotid arterial stiffness and structure in spontaneous hypertensive rats (SHR). Carotid arterial stiffness was studied in SHR receiving a HSD or a normal-salt diet (NSD) from the 10th to 20th week of age. Within each of the 2 groups, the animals received treatment with either placebo or valsartan (30 mg. kg(-1). d(-1)) administered on the 4th to 20th week of age. Arterial pressure, wall stress, incremental elastic modulus (Einc), medial cross-sectional area, and EIIIA fibronectin isoform were significantly increased in placebo-HSD rats compared with placebo-NSD rats with no change in the ratio of collagen to elastin. Valsartan reduced mean arterial pressure in both NSD and HSD rats but reduced pulse pressure only in NSD rats. In NSD rats, valsartan reduced Einc and medial cross-sectional area. In HSD, valsartan increased Einc and did not modify medial cross-sectional area and fibronectin. In valsartan-treated rats, the ratio of collagen to elastin was greater in HSD than in NSD rats. In conclusion, the effects of AT(1) blockade are greatly influenced by salt intake in SHR. Despite a reduction in mean arterial pressure in HSD rats, AT(1) blockade was not able to prevent the effects of a HSD on pulse pressure, carotid artery stiffness, and hypertrophy.
- Subjects :
- Animals
Antihypertensive Agents therapeutic use
Aorta, Thoracic chemistry
Aorta, Thoracic pathology
Blood Pressure drug effects
Body Weight drug effects
Carotid Arteries pathology
Carotid Arteries physiopathology
Dose-Response Relationship, Drug
Fibronectins analysis
Hypertension physiopathology
Immunohistochemistry
Male
Protein Isoforms analysis
Rats
Rats, Inbred SHR
Tetrazoles therapeutic use
Valine analogs & derivatives
Valine therapeutic use
Valsartan
Antihypertensive Agents pharmacology
Carotid Arteries drug effects
Hypertension drug therapy
Sodium Chloride, Dietary administration & dosage
Tetrazoles pharmacology
Valine pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1524-4563
- Volume :
- 38
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Hypertension (Dallas, Tex. : 1979)
- Publication Type :
- Academic Journal
- Accession number :
- 11566919
- Full Text :
- https://doi.org/10.1161/01.hyp.38.3.439