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Design of new mononucleotide prodrugs: aryl (SATE) phosphotriester derivatives.
- Source :
-
Nucleosides, nucleotides & nucleic acids [Nucleosides Nucleotides Nucleic Acids] 2001 Apr-Jul; Vol. 20 (4-7), pp. 315-21. - Publication Year :
- 2001
-
Abstract
- Synthesis, biological activities and decomposition kinetics of novel phosphotriester derivatives of 3'-azido-2',3'-dideoxythymidine (AZT) bearing a S-tButyl-2-thioethyl (tBuSATE) group and L-tyrosinyl residues are reported. All the derivatives appeared to be potent inhibitors of HIV-1 replication in various cell culture experiments. The proposed decomposition process of these mixed phosphotriesters may involve successively an esterase and then a phosphodiesterase activation.
- Subjects :
- Anti-HIV Agents chemistry
Cells, Cultured
Drug Design
Drug Stability
Esters chemical synthesis
Esters chemistry
Esters pharmacology
HIV-1 drug effects
HIV-1 physiology
Humans
Prodrugs chemistry
Virus Replication drug effects
Zidovudine chemical synthesis
Zidovudine pharmacology
Anti-HIV Agents chemical synthesis
Anti-HIV Agents pharmacology
Prodrugs chemical synthesis
Prodrugs pharmacology
Zidovudine analogs & derivatives
Subjects
Details
- Language :
- English
- ISSN :
- 1525-7770
- Volume :
- 20
- Issue :
- 4-7
- Database :
- MEDLINE
- Journal :
- Nucleosides, nucleotides & nucleic acids
- Publication Type :
- Academic Journal
- Accession number :
- 11563043
- Full Text :
- https://doi.org/10.1081/NCN-100002302