[Anti-arboviral properties of different substances of chemical and plant origin].

Authors :: Vynograd IA
Plastunov VA
Kozlovs'kiĭ MM
Benzel' LV
Bilets'ka GV
Lozyns'kiĭ IM
Rogochiĭ IeG
Sholomeĭ MD
Source :: Mikrobiolohichnyi zhurnal (Kiev, Ukraine : 1993) [Mikrobiol Z] 2001 Mar-Apr; Vol. 63 (2), pp. 14-9.
Publication Year :: 2001
Abstract: The paper deals with the results of search for inhibitors of two arboviral infections, including Alfavirus of Venezuelan equine encephalomyelitis (family Togaviridae) and Bunyavirus Tahyna (family Bunyaviridae), interferon inducers among 99 substances of organic synthesis and 92 compounds of plant origin. Antiarboviral activity of some of these chemicals were investigated as well. Reproduction of the studied viruses in cell culture was inhibited by 8 derivatives of triazole, triazine and uracile (UPI-264 and UPI-273, PV-166, PV-169, PV-171, PV-184, PV-188 and PV-214) and 21 plant remedies (lyophilizates ASHCH-1, BL-1, VN, GAL-1, GAPr-1, GACH-1, GVPr-1, GVCH-1, GM-1, GCA-2, GCV-2, LGSHCHA, LSHCH-6, KIS-1, KJL-1, KKL-1, RDO-1, SX-2, SHCHKS-1, YA and YAN).

Subjects :: Animals
Cells, Cultured
Chlorocebus aethiops
Drug Evaluation, Preclinical
Interferon Inducers therapeutic use
Mice
Phytotherapy
Plant Preparations therapeutic use
Triazines pharmacology
Triazines therapeutic use
Triazoles pharmacology
Triazoles therapeutic use
Uracil analogs & derivatives
Uracil therapeutic use
Vero Cells
Antiviral Agents pharmacology
Arbovirus Infections drug therapy
Arboviruses drug effects
Interferon Inducers pharmacology

Tools