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Age-dependent renal responses to the bradykinin B(2)- receptor antagonist icatibant in conscious lambs.
- Source :
-
American journal of physiology. Regulatory, integrative and comparative physiology [Am J Physiol Regul Integr Comp Physiol] 2001 Oct; Vol. 281 (4), pp. R1311-8. - Publication Year :
- 2001
-
Abstract
- To investigate the role of endogenously produced bradykinin in modulating renal function during postnatal maturation, various parameters of glomerular and tubular function were measured for 1 h before and after intravenous injection of 12.5 microg/kg of the specific B(2)-receptor antagonist icatibant to conscious, chronically instrumented lambs aged approximately 1 (n = 7) and approximately 6 wk (n = 7). In response to icatibant, and in the absence of any changes in renal hemodynamics, there was an approximately 80% decrease in glomerular filtration rate (GFR) at 20 min in 1-wk-old lambs that was sustained for 60 min; in 6-wk-old lambs, there was an approximately 70% decrease in GFR by 20 min, with control levels being reached by 40 min. Icatibant administration was also associated with significant decreases in urinary flow, Cl(-), and K(+) excretion rates that were similar in both groups of lambs, whereas Na(+) excretion decreased only in 6-wk-old lambs. We conclude that bradykinin modulates glomerular and tubular function in an age-dependent manner.
- Subjects :
- Animals
Bradykinin analogs & derivatives
Chlorides metabolism
Diuresis drug effects
Glomerular Filtration Rate drug effects
Hematocrit
Hemodynamics drug effects
Hemodynamics physiology
Kidney Tubules drug effects
Kidney Tubules physiology
Potassium metabolism
Prostaglandins E blood
Receptor, Bradykinin B2
Renin blood
Sheep
Aging physiology
Bradykinin pharmacology
Bradykinin Receptor Antagonists
Consciousness
Kidney drug effects
Kidney physiology
Subjects
Details
- Language :
- English
- ISSN :
- 0363-6119
- Volume :
- 281
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- American journal of physiology. Regulatory, integrative and comparative physiology
- Publication Type :
- Academic Journal
- Accession number :
- 11557641
- Full Text :
- https://doi.org/10.1152/ajpregu.2001.281.4.R1311