A novel arsenical in clam kidney identified by liquid chromatography/electrospray ionisation mass spectrometry.

Authors :: Francesconi KA
Edmonds JS
Source :: Rapid communications in mass spectrometry : RCM [Rapid Commun Mass Spectrom] 2001; Vol. 15 (17), pp. 1641-6.
Publication Year :: 2001
Abstract: Kidneys of clams of the genus Tridacna accumulate metabolic products from symbiotic unicellular algae that grow in the mantles of the clams. These metabolites include organoarsenic compounds that are biosynthesised by algae from arsenate in seawater. The arsenic compounds in aqueous extracts of the kidney of the giant clam T. derasa were investigated by liquid chromatography/electrospray ionisation mass spectrometry. About 50% of the water-soluble arsenic was present as dimethylarsinoylribosides and dimethylarsinate which are common algal metabolites. The major compound in the kidney (50% of water-soluble arsenic) was identified as a 5-dimethylarsinoyl-2,3,4-trihydroxycarboxylic acid, a new natural product.<br /> (Copyright 2001 John Wiley & Sons, Ltd.)

Subjects :: Animals
Arsenicals analysis
Cacodylic Acid analogs & derivatives
Cacodylic Acid analysis
Pentanoic Acids analysis
Arsenicals metabolism
Bivalvia metabolism
Cacodylic Acid metabolism
Chromatography, Liquid methods
Kidney metabolism
Pentanoic Acids metabolism
Spectrometry, Mass, Electrospray Ionization methods

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