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Susceptibility to subsequent episodes of spontaneous recurrence of methamphetamine psychosis.
- Source :
-
Drug and alcohol dependence [Drug Alcohol Depend] 2001 Oct 01; Vol. 64 (2), pp. 133-42. - Publication Year :
- 2001
-
Abstract
- We examine susceptibility to subsequent spontaneous recurrences of methamphetamine psychosis (i.e. flashbacks) in 11 flashbackers with a single episode and in nine flashbackers with subsequent episodes. All had undergone frightening stressful experiences during previous MAP use. Mild psychosocial stressors then triggered flashbacks. During flashbacks, the nine flashbackers with subsequent episodes had more markedly increased norepinephrine levels, with slightly increased 3-methoxytyramine levels. The duration of imprisonment in this subgroup approached significantly long levels than in the 11 flashbackers with a single episode. Robust noradrenergic hyperactivity with slightly increased dopamine release may therefore predict subsequent flashbacks. Longer exposure to distressing situations may also contribute to robust noradrenergic hyperactivity.
- Subjects :
- 3,4-Dihydroxyphenylacetic Acid blood
Adult
Arousal drug effects
Arousal physiology
Dopamine blood
Female
Humans
Life Change Events
Norepinephrine blood
Prisoners psychology
Psychoses, Substance-Induced blood
Psychoses, Substance-Induced diagnosis
Recurrence
Risk Factors
Dopamine analogs & derivatives
Methamphetamine adverse effects
Psychoses, Substance-Induced etiology
Subjects
Details
- Language :
- English
- ISSN :
- 0376-8716
- Volume :
- 64
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Drug and alcohol dependence
- Publication Type :
- Academic Journal
- Accession number :
- 11543983
- Full Text :
- https://doi.org/10.1016/s0376-8716(00)00240-4