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Dopamine D(2) receptor availability and amphetamine-induced dopamine release in unipolar depression.
- Source :
-
Biological psychiatry [Biol Psychiatry] 2001 Sep 01; Vol. 50 (5), pp. 313-22. - Publication Year :
- 2001
-
Abstract
- Background: Reduced dopaminergic transmission has been implicated in the pathophysiology of major depression. The aim of the present study was to measure striatal D(2) receptor availability and amphetamine-induced dopamine release in nonpsychotic, unmedicated, unipolar patients during an episode of major depression.<br />Methods: The striatal equilibrium specific to nonspecific partition coefficient (V(3)") of the D(2) receptor antagonist [(123)I]IBZM was measured with single photon emission computerized tomography before and after amphetamine administration in 9 depressed subjects and 10 matched healthy control subjects.<br />Results: No significant differences were observed in preamphetamine D(2) receptor availability between depressed patients (0.73 +/- 0.08) and control subjects (0.78 +/- 0.10, p =.23). Amphetamine-induced reduction in [(123)I]IBZM V(3)" (DeltaV(3)") was similar in depressed patients (-9.8 +/- 5.5%) and control subjects (-7.8 +/- 2.5%, p =.32). Amphetamine induced a transient improvement in symptomatology in depressed patients, but this improvement did not correlate with [(123)I]IBZM DeltaV(3)".<br />Conclusions: This study did not replicate previously reported alterations in striatal D(2) receptor density in depressed patients and suggests that stimulant-induced dopamine release is not altered in major depression.
- Subjects :
- Adolescent
Adult
Amphetamine pharmacokinetics
Benzamides
Corpus Striatum diagnostic imaging
Depressive Disorder, Major diagnostic imaging
Depressive Disorder, Major psychology
Female
Humans
Iodine Radioisotopes
Male
Middle Aged
Pyrrolidines
Receptors, Dopamine D2 drug effects
Synaptic Transmission drug effects
Synaptic Transmission physiology
Amphetamine pharmacology
Corpus Striatum physiopathology
Depressive Disorder, Major physiopathology
Dopamine metabolism
Receptors, Dopamine D2 physiology
Tomography, Emission-Computed, Single-Photon
Subjects
Details
- Language :
- English
- ISSN :
- 0006-3223
- Volume :
- 50
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Biological psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- 11543733
- Full Text :
- https://doi.org/10.1016/s0006-3223(01)01089-7