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[Computer simulation of cardiovascular response to lower body negative pressure].
- Source :
-
Hang tian yi xue yu yi xue gong cheng = Space medicine & medical engineering [Space Med Med Eng (Beijing)] 1999 Aug; Vol. 12 (4), pp. 262-6. - Publication Year :
- 1999
-
Abstract
- Objective: To simulate the cardiovascular response to lower body negative pressure (LBNP).<br />Method: A computer model was developed. It had 7 subparts: the redistribution of blood, the filling of left ventricle, left ventricle, peripheral circulation, control of heart rate, control of peripheral resistance and control of venous tone. The heart rate and venous tone were controlled by high-pressure receptor baroreflex, while the peripheral resistance was controlled by high- and low-pressure receptor baroreflexes.<br />Result: With the help of the model, cardiovascular response to LBNP up to -10.64 kPa (-80 mmHg) were simulated, including the changes of systolic blood pressure, mean blood pressure, heart rate and cardiac output. The time-dependent response to a LBNP profile was also simulated. The simulation results coincided well with human experiments.<br />Conclusion: The model is valid and can accurately reproduce the short-term hemodynamic response to LBNP.
- Subjects :
- Aerospace Medicine
Baroreflex physiology
Blood Pressure physiology
Cardiac Output physiology
Evaluation Studies as Topic
Heart Rate physiology
Humans
Vascular Resistance physiology
Ventricular Function, Left physiology
Cardiovascular Physiological Phenomena
Computer Simulation
Lower Body Negative Pressure
Models, Cardiovascular
Subjects
Details
- Language :
- Chinese
- ISSN :
- 1002-0837
- Volume :
- 12
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Hang tian yi xue yu yi xue gong cheng = Space medicine & medical engineering
- Publication Type :
- Academic Journal
- Accession number :
- 11542707