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Bisphenol-A differently affects estrogen receptors-alpha in estrous-cycling and lactating female rats.
- Source :
-
Neuroscience letters [Neurosci Lett] 2001 Sep 07; Vol. 310 (1), pp. 49-52. - Publication Year :
- 2001
-
Abstract
- The effect of long-term exposure to bisphenol-A (BPA) on estrogen receptor-alpha (ER) immunoreactivity was studied in the medial preoptic area, arcuate nucleus and the ventromedial nucleus of the hypothalamus of estrous cycling and lactating female rats. Pregnant/lactating or estrous cycling rats were exposed to BPA (40 mg/Kg/day) or peanut oil. Lactating females showed fewer ER-immunoreactive cells than non-lactating females in the medial preoptic area and ventromedial nucleus of the hypothalamus. BPA induced an increase in ER-immunoreactive cells in the medial preoptic nucleus irrespective of lactation. BPA only induced a decrease in ER-immunoreactive cells in the arcuate nucleus of the lactating group; oil induced an increase in ER-immunoreactive cells in the lactating with respect to non-lactating group. The results demonstrate that exposure of adult females to BPA modifies the number of ERs.
Details
- Language :
- English
- ISSN :
- 0304-3940
- Volume :
- 310
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Neuroscience letters
- Publication Type :
- Academic Journal
- Accession number :
- 11524155
- Full Text :
- https://doi.org/10.1016/s0304-3940(01)02092-4