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Painless thyroiditis associated with severe inflammatory reactions in amyloid goiter: a case report.
- Source :
-
Endocrine journal [Endocr J] 2001 Jun; Vol. 48 (3), pp. 323-9. - Publication Year :
- 2001
-
Abstract
- We report the case of a 64-year-old woman with rheumatoid arthritis (RA) associated with high grade fever, malaise, and painless swelling of thyroid gland. Laboratory findings showed severe systemic inflammatory reactions, including increases in various cytokines such as IL-6. Gallium-67 citrate imaging revealed intense uptake in the painlessly enlarged thyroid gland. Histologically, biopsied specimens of thyroid showed diffuse amyloid infiltrations, which included amyloid A (AA) protein. Biopsies of rectum and stomach revealed similar amyloid depositions, indicating that the amyloid had a secondary origin, potentially due to RA. All clinical symptoms were relieved by intravenous pulsatile administration of methylprednisolone followed by oral prednisone, resulting in prolonged hypothyroid status. To our knowledge, this is the first case report in Japan describing painless thyroiditis with severe inflammatory reactions in amyloid goiter.
- Subjects :
- Amyloid analysis
Amyloidosis metabolism
Amyloidosis pathology
Arthritis, Rheumatoid complications
Biopsy
Female
Gallium Radioisotopes
Goiter metabolism
Goiter pathology
Humans
Interleukin-6 metabolism
Methylprednisolone administration & dosage
Methylprednisolone therapeutic use
Middle Aged
Prednisolone administration & dosage
Prednisolone therapeutic use
Rectum chemistry
Rectum pathology
Stomach chemistry
Stomach pathology
Thyroid Gland pathology
Thyroiditis diagnosis
Thyroiditis pathology
Tomography, X-Ray Computed
Amyloidosis complications
Goiter complications
Inflammation complications
Thyroiditis complications
Subjects
Details
- Language :
- English
- ISSN :
- 0918-8959
- Volume :
- 48
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Endocrine journal
- Publication Type :
- Academic Journal
- Accession number :
- 11523903
- Full Text :
- https://doi.org/10.1507/endocrj.48.323