Back to Search
Start Over
Subversion of the T/B lineage decision in the thymus by lunatic fringe-mediated inhibition of Notch-1.
- Source :
-
Immunity [Immunity] 2001 Aug; Vol. 15 (2), pp. 225-36. - Publication Year :
- 2001
-
Abstract
- Notch-1 signaling is essential for lymphoid progenitors to undergo T cell commitment, but the mechanism has not been defined. Here we show that thymocytes ectopically expressing Lunatic Fringe, a modifier of Notch-1 signaling, induce lymphoid progenitors to develop into B cells in the thymus. This cell fate switch resulted from Lunatic Fringe-mediated inhibition of Notch-1 function, as revealed by experiments utilizing lymphoid progenitors in which Notch-1 activity was genetically manipulated. These data identify Lunatic Fringe as a potent regulator of Notch-1 during the T/B lineage decision and show that an important function of Notch-1 in T cell commitment is to suppress B cell development in the thymus.
- Subjects :
- Animals
B-Lymphocytes immunology
Bone Marrow Cells
Cell Differentiation
Cell Lineage
Mice
Mice, Transgenic
Models, Immunological
Proteins genetics
Receptor, Notch1
Recombinant Proteins metabolism
T-Lymphocytes immunology
Thymus Gland cytology
B-Lymphocytes cytology
Glycosyltransferases
Membrane Proteins antagonists & inhibitors
Proteins metabolism
Receptors, Cell Surface
T-Lymphocytes cytology
Thymus Gland immunology
Transcription Factors
Subjects
Details
- Language :
- English
- ISSN :
- 1074-7613
- Volume :
- 15
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Immunity
- Publication Type :
- Academic Journal
- Accession number :
- 11520458
- Full Text :
- https://doi.org/10.1016/s1074-7613(01)00189-3