NMR spectroscopic analysis of 2-mercapto-5-methyl-1,3,4-thiadiazole in cefazolin.

Authors :: Staiger DB
Warren RJ
Zarembo JE
Post A
Source :: Journal of pharmaceutical sciences [J Pharm Sci] 1975 Aug; Vol. 64 (8), pp. 1396-7.
Publication Year :: 1975
Abstract: A rapid, sensitive, and accurate method for the quantitative analysis of 2-mercapto-5-methyl-1,3,4-thiadiazole in cefazolin is presented. The method utilizes NMR spectroscopy and is based on the difference in the chemical shift of the methyl protons on free thiadiazole and the thiadiazole moiety of cefazolin.

Subjects :: Magnetic Resonance Spectroscopy
Methods
Cefazolin analysis
Cephalosporins analysis
Sulfhydryl Compounds analysis
Thiadiazoles analysis

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