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1,4-Disubstituted imidazoles are potential antibacterial agents functioning as inhibitors of enoyl acyl carrier protein reductase (FabI).
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2001 Aug 20; Vol. 11 (16), pp. 2061-5. - Publication Year :
- 2001
-
Abstract
- 1,4-Disubstituted imidazole inhibitors of Staphylococcus aureus and Escherichia coli enoyl acyl carrier protein reductase (FabI) have been identified. Crystal structure data shows the inhibitor 1 bound in the enzyme active site of E. coli FabI.
- Subjects :
- Anti-Bacterial Agents chemical synthesis
Anti-Bacterial Agents chemistry
Enoyl-(Acyl-Carrier-Protein) Reductase (NADH)
Enzyme Inhibitors chemical synthesis
Enzyme Inhibitors chemistry
Enzyme Inhibitors pharmacology
Escherichia coli drug effects
Escherichia coli Proteins
Fatty Acid Synthase, Type II
Imidazoles chemical synthesis
Imidazoles chemistry
Microbial Sensitivity Tests
Staphylococcus aureus drug effects
Anti-Bacterial Agents pharmacology
Imidazoles pharmacology
Oxidoreductases antagonists & inhibitors
Subjects
Details
- Language :
- English
- ISSN :
- 0960-894X
- Volume :
- 11
- Issue :
- 16
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 11514139
- Full Text :
- https://doi.org/10.1016/s0960-894x(01)00404-8