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Expression of the G1-S modulators in hepatitis B virus-related hepatocellular carcinoma and dysplastic nodule: association of cyclin D1 and p53 proteins with the progression of hepatocellular carcinoma.
- Source :
-
Journal of Korean medical science [J Korean Med Sci] 2001 Aug; Vol. 16 (4), pp. 424-32. - Publication Year :
- 2001
-
Abstract
- Deranged expression of cell cycle modulators has been reported to contribute to the development and progression of hepatocellular carcinoma (HCC). However, their expression patterns remain poorly understood in hepatitis B virus (HBV)-related HCC, which constitutes about 65-70% of HCC in Korea. The aims of this study were to evaluate the expressions of G1-S modulators in HBV-related HCCs and dysplastic nodules (DNs), and to correlate with the histopathologic features of HCCs. Immunohistochemical expressions of cyclin D1, cyclin E, p53, p27, p21, p16, Rb, and PCNA proteins were investigated in 80 HCCs and 22 DNs. Cyclin D1 overexpression showed positive relationships with advanced tumor stage, poor differentiation, larger tumor size, microvascular invasion, intrahepatic meta-stasis, no tumor capsule formation, infiltrative growth, aberrant p53 expression, and high PCNA labeling index (LI) of HCC (p<0.05). Aberrant p53 expression showed positive relationship with poor differentiation of HCC (p<0.01). Expression of cyclin D1 or p53 was not observed in DNs. The p27 LI and p16 LI were lower in HCCs with intrahepatic metastasis (p<0.05). Cyclin D1 overexpression and aberrant p53 expression could be associated with the progression of HBV-related HCC, and might have a less crucial role in the DN-HCC sequence. In addition, elevated expression of p27 and p16 proteins might have inhibitory action to the intrahepatic metastasis of HBV-related HCC.
- Subjects :
- Adult
Aged
Carcinoma, Hepatocellular chemistry
Carcinoma, Hepatocellular etiology
Cyclin-Dependent Kinase Inhibitor p16 analysis
Female
G1 Phase
Humans
Immunohistochemistry
Liver Neoplasms chemistry
Liver Neoplasms etiology
Male
Microfilament Proteins analysis
Middle Aged
Proliferating Cell Nuclear Antigen analysis
Retinoblastoma Protein analysis
S Phase
Carcinoma, Hepatocellular pathology
Cyclin D1 analysis
Hepatitis B complications
Liver Neoplasms pathology
Muscle Proteins
Precancerous Conditions virology
Tumor Suppressor Protein p53 analysis
Subjects
Details
- Language :
- English
- ISSN :
- 1011-8934
- Volume :
- 16
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Journal of Korean medical science
- Publication Type :
- Academic Journal
- Accession number :
- 11511787
- Full Text :
- https://doi.org/10.3346/jkms.2001.16.4.424