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Gentamicin pharmacokinetics in rats with reduced renal parenchyma.

Gentamicin pharmacokinetics in rats with reduced renal parenchyma.

Authors :
Hatala M
Morávek J
Schück O
Source :
International journal of clinical pharmacology and biopharmacy [Int J Clin Pharmacol Biopharm] 1975 Jan; Vol. 11 (1), pp. 1-6.
Publication Year :
1975

Abstract

Pharmacokinetics of intramuscular gentamicin was observed in healty rats, in rats with renal parenchyma reduced to 1/5 of normal and in rats after bilateral nephrectomy. The results obtained support the assumption that in rats gentamicin is excreted only through the kidneys. Reduction of the renal parenchyma to 1/5 of normal is associated with extention of biological half-life only to double the control value. The results support the hypothesis that in the given experimental conditions gentamicin excretion in residual nephrons increases.

Details

Language :
English
ISSN :
0340-0026
Volume :
11
Issue :
1
Database :
MEDLINE
Journal :
International journal of clinical pharmacology and biopharmacy
Publication Type :
Academic Journal
Accession number :
1150358