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Gentamicin pharmacokinetics in rats with reduced renal parenchyma.
Gentamicin pharmacokinetics in rats with reduced renal parenchyma.
- Source :
-
International journal of clinical pharmacology and biopharmacy [Int J Clin Pharmacol Biopharm] 1975 Jan; Vol. 11 (1), pp. 1-6. - Publication Year :
- 1975
-
Abstract
- Pharmacokinetics of intramuscular gentamicin was observed in healty rats, in rats with renal parenchyma reduced to 1/5 of normal and in rats after bilateral nephrectomy. The results obtained support the assumption that in rats gentamicin is excreted only through the kidneys. Reduction of the renal parenchyma to 1/5 of normal is associated with extention of biological half-life only to double the control value. The results support the hypothesis that in the given experimental conditions gentamicin excretion in residual nephrons increases.
Details
- Language :
- English
- ISSN :
- 0340-0026
- Volume :
- 11
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- International journal of clinical pharmacology and biopharmacy
- Publication Type :
- Academic Journal
- Accession number :
- 1150358