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[Effect of Fucong tablets and its ingredients on ototoxicity of gentamycin in guinea pigs].
- Source :
-
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine [Zhongguo Zhong Xi Yi Jie He Za Zhi] 1998 Jun; Vol. 18 (6), pp. 365-7. - Publication Year :
- 1998
-
Abstract
- Objective: To assess the antagonistic effect of Fucong Tablet (FCT) and its ingredients on ototoxicity of gentamycin in guinea pigs.<br />Methods: The guinea pigs were given gentamycin 80 mg/kg intramuscularly once daily for 20 days and FCT or its ingredients separately oral taken for 20 days. The auditory brain stem evoked response (ABR) threshold, vascular stria blood circulation condition, outer hair-cell count and cochlear ultrastructure of guinea pigs were observed before and after treatment to assess the antagonistic effect and protective effect of FCT on cochlear structure.<br />Results: FCT and its ingredients of tonifying Kidney, replenishing Qi and blood, promoting blood circulation could lower the impairment ratio of outer hair-cell induced by gentamycin (P < 0.05), protect morphosis and function of cochlea and lower the elevated ABR threshold (P < 0.05).<br />Conclusions: FCT and its ingredients could reduce the toxic damage on ear induced by gentamycin effectively.
- Subjects :
- Animals
Cochlea physiopathology
Cochlear Diseases chemically induced
Cochlear Diseases drug therapy
Cochlear Diseases pathology
Drugs, Chinese Herbal therapeutic use
Female
Guinea Pigs
Hair Cells, Auditory, Outer ultrastructure
Hearing Loss, Bilateral chemically induced
Hearing Loss, Bilateral drug therapy
Male
Random Allocation
Cochlea ultrastructure
Drugs, Chinese Herbal pharmacology
Evoked Potentials, Auditory, Brain Stem
Gentamicins adverse effects
Hearing Loss, Bilateral pathology
Subjects
Details
- Language :
- Chinese
- ISSN :
- 1003-5370
- Volume :
- 18
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine
- Publication Type :
- Academic Journal
- Accession number :
- 11477915