Back to Search
Start Over
Importance of the cytochrome P450 2D6 genotype for the drug metabolic interaction between chlorpromazine and haloperidol.
- Source :
-
Therapeutic drug monitoring [Ther Drug Monit] 2001 Aug; Vol. 23 (4), pp. 363-8. - Publication Year :
- 2001
-
Abstract
- The authors studied the interactive effects of the coadministration of haloperidol and chlorpromazine on plasma concentrations of haloperidol and reduced haloperidol. The subjects were 43 Japanese male schizophrenic inpatients who were concomitantly treated with chlorpromazine before or after monotherapy with haloperidol. Coadministration of chlorpromazine produced significant increases in the plasma concentrations of haloperidol (P < 0.01) and reduced haloperidol (P < 0.001) by an average of 28.5% +/- 83.3% and 160.8% +/- 288.9%, respectively. However, there were marked interindividual variations in the interactive effects of chlorpromazine. The authors analyzed the importance of five CYP2D6 genotypes, *1/ *1, *1/ *10, *10/ *10, *1/*5, and *5/*10 on the percentage of change in plasma concentrations of haloperidol and reduced haloperidol. Patients with the CYP2D6*5 allele (n = 4) showed a significantly smaller increase in plasma concentrations of haloperidol (P < 0.05) and a slightly smaller increase in those of reduced haloperidol (P = 0.074) in response to the coadministration of chlorpromazine compared than those with the CYP2D6*1/*1 genotype (n = 8). Those with the CYP2D6*1/*1 genotype (n = 8) showed a trend toward greater increases in plasma concentrations of haloperidol than those with other genotypes (P = 0.087).
- Subjects :
- Adult
Aged
Antipsychotic Agents pharmacokinetics
Drug Interactions
Drug Therapy, Combination
Genotype
Haloperidol pharmacokinetics
Humans
Middle Aged
Schizophrenia drug therapy
Schizophrenia metabolism
Antipsychotic Agents therapeutic use
Chlorpromazine therapeutic use
Cytochrome P-450 CYP2D6 genetics
Haloperidol therapeutic use
Schizophrenia enzymology
Subjects
Details
- Language :
- English
- ISSN :
- 0163-4356
- Volume :
- 23
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Therapeutic drug monitoring
- Publication Type :
- Academic Journal
- Accession number :
- 11477317
- Full Text :
- https://doi.org/10.1097/00007691-200108000-00007