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Synthesis and evaluation of novel quinolinones as HIV-1 reverse transcriptase inhibitors.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2001 Jul 23; Vol. 11 (14), pp. 1943-5. - Publication Year :
- 2001
-
Abstract
- A series of 4,4-disubstituted quinolinones was prepared and evaluated as HIV-1 reverse transcriptase inhibitors. The C-3 substituted compound 9h displayed improved antiviral activity against clinically significant single (K103N) and double (K103N/L100I) mutant viruses.
Details
- Language :
- English
- ISSN :
- 0960-894X
- Volume :
- 11
- Issue :
- 14
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 11459666
- Full Text :
- https://doi.org/10.1016/s0960-894x(01)00331-6