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Association of adiposity assessed by means of near-infrared interactance with the beta-cell function, insulin resistance and leptin concentrations in non-obese subjects. Exploratory study.
- Source :
-
Journal of diabetes and its complications [J Diabetes Complications] 2001 Jul-Aug; Vol. 15 (4), pp. 181-4. - Publication Year :
- 2001
-
Abstract
- The objective was to identify the association of adiposity with the beta-cell function, insulin resistance and leptin concentrations in non-obese subjects. Twenty-eight healthy, non-obese volunteers were recruited, 14 male and 14 female. Body mass index (BMI) and waist hip ratio (WHR) were calculated. Blood pressure was measured. Adiposity was estimated by means of near-infrared (NIR) interactance method predicting the percentage of body fat (% BF). All subjects were divided into adipose and non-adipose individuals. Serum glucose, insulin and leptin levels were measured. Formulas of the homeostasis model analysis were used to assess the insulin resistance and the beta-cell function. Clinical characteristics and laboratory profile were similar between both groups. There were no significant differences between both groups in beta-cell function, insulin resistance and leptin concentrations. There was a positive significant correlation of % BF with BMI in women (r= .82, P< .001) and in men (r= .85, P< .001). Adiposity was not associated with the beta-cell function, insulin resistance and leptin concentrations in non-obese subjects, and only percent body fat was positive correlated with BMI.
- Subjects :
- Adult
Blood Glucose analysis
Blood Pressure
Body Constitution
Body Height
Body Mass Index
Body Weight
Female
Homeostasis
Humans
Male
Reference Values
Regression Analysis
Sex Factors
Spectroscopy, Near-Infrared methods
Adipose Tissue anatomy & histology
Insulin blood
Insulin Resistance physiology
Islets of Langerhans metabolism
Leptin blood
Subjects
Details
- Language :
- English
- ISSN :
- 1056-8727
- Volume :
- 15
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Journal of diabetes and its complications
- Publication Type :
- Academic Journal
- Accession number :
- 11457669
- Full Text :
- https://doi.org/10.1016/s1056-8727(00)00144-6