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Attention-deficit hyperactivity disorder: a study of association with both the dopamine transporter gene and the dopamine D4 receptor gene.
- Source :
-
American journal of medical genetics [Am J Med Genet] 2001 Jul 08; Vol. 105 (5), pp. 471-8. - Publication Year :
- 2001
-
Abstract
- Attention-deficit hyperactivity disorder (ADHD) is one of the most common psychiatric disorders of childhood. The role of genetic factors in its etiology is strongly supported by family, adoption, and twin studies. Several investigations have reported associations between ADHD and both the 7-repeat allele of the 48 bp VNTR at the DRD4 gene and the 10-repeat allele of the 40 bp VNTR at the DAT1 gene, but the results have been inconsistent. A sample of 81 Brazilian ADHD children and adolescents and their parents were screened for these DRD4 and DAT1 VNTRs. An excess of the DRD4 7-repeat allele was observed when both ADHD probands and their parents were compared with an ethnically matched control sample (chi-square = 11.55, P = 0.03; chi-square = 12.17, P = 0.03, respectively). However, haplotype relative risk (HRR) analysis showed no preferential transmission of the DRD4 7-repeat allele. No evidence of association with the DAT1 polymorphism was detected by both approaches. Nevertheless, an interaction effect of both genes on ADHD hyperactive/impulsive dimension was observed (F = 4.68; P = 0.03). These results add to the group of studies that together suggest a small effect of these genes in the susceptibility to ADHD.<br /> (Copyright 2001 Wiley-Liss, Inc.)
- Subjects :
- Adolescent
Alleles
Attention Deficit Disorder with Hyperactivity pathology
Carrier Proteins genetics
Child
DNA genetics
Dopamine Plasma Membrane Transport Proteins
Family Health
Female
Gene Frequency
Genotype
Humans
Male
Receptors, Dopamine D2 genetics
Receptors, Dopamine D4
Attention Deficit Disorder with Hyperactivity genetics
Membrane Glycoproteins
Membrane Transport Proteins
Nerve Tissue Proteins
Subjects
Details
- Language :
- English
- ISSN :
- 0148-7299
- Volume :
- 105
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- American journal of medical genetics
- Publication Type :
- Academic Journal
- Accession number :
- 11449401
- Full Text :
- https://doi.org/10.1002/ajmg.1408