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Fatal submassive hepatic necrosis associated with tyrosine-methionine-aspartate-aspartate-motif mutation of hepatitis B virus after long-term lamivudine therapy.
- Source :
-
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [Clin Infect Dis] 2001 Aug 01; Vol. 33 (3), pp. 403-5. Date of Electronic Publication: 2001 Jul 07. - Publication Year :
- 2001
-
Abstract
- We present a case of infection with lamivudine-resistant mutant hepatitis B virus (HBV) that fatally exacerbated hepatitis following the emergence of HBV with mutations in the tyrosine-methionine-aspartate-aspartate (YMDD) motif in an immunocompetent patient who was receiving long-term lamivudine therapy. Restriction fragment length polymorphism analysis showed that the YMDD-motif mutant was the predominant form of circulating HBV at the time of the fatal exacerbation, and a necropsy specimen of the liver revealed submassive hepatic necrosis without steatosis.
- Subjects :
- Amino Acid Motifs genetics
Antiviral Agents pharmacology
Drug Resistance, Microbial
Fatal Outcome
Hepatitis B, Chronic pathology
Hepatitis B, Chronic physiopathology
Humans
Immunocompetence
Lamivudine pharmacology
Male
Middle Aged
Mutation
Necrosis
Polymorphism, Restriction Fragment Length
Reverse Transcriptase Inhibitors pharmacology
Antiviral Agents therapeutic use
Hepatitis B virus drug effects
Hepatitis B virus genetics
Hepatitis B, Chronic drug therapy
Lamivudine therapeutic use
Reverse Transcriptase Inhibitors therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1058-4838
- Volume :
- 33
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
- Publication Type :
- Academic Journal
- Accession number :
- 11438912
- Full Text :
- https://doi.org/10.1086/321879