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Functions of uterine natural killer cells are mediated by interferon gamma production during murine pregnancy.
- Source :
-
Seminars in immunology [Semin Immunol] 2001 Aug; Vol. 13 (4), pp. 235-41. - Publication Year :
- 2001
-
Abstract
- The dominant lymphocytes in healthy human and murine implantation sites are pregnancy-associated uterine natural killer (uNK) cells. These cells produce 90% of pregnancy-induced, uterine interferon (IFN)- gamma, a cytokine that regulates expression of more than 0.5% of the mouse genome. Implantation sites in uNK cell-deficient and IFN- gamma -signal-disrupted mice display anomalies in decidua and its spiral arteries. Reconstitution of uNK cell-deficient females with bone marrow containing normal NK cell progenitors, establishes uNK cells and reverses the anomalies. Grafts from IFN- gamma(-/-)mice are restored uNK cells, but the uNK cells did not reverse the phenotypes. This review focuses on the functions of uNK cell-derived IFN- gamma and the genes that it may regulate in the pregnant uterus.<br /> (Copyright 2001 Academic Press.)
Details
- Language :
- English
- ISSN :
- 1044-5323
- Volume :
- 13
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Seminars in immunology
- Publication Type :
- Academic Journal
- Accession number :
- 11437631
- Full Text :
- https://doi.org/10.1006/smim.2000.0319