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A novel anti-HIV macrocyclic peptide from Palicourea condensata.
- Source :
-
Journal of natural products [J Nat Prod] 2001 Feb; Vol. 64 (2), pp. 249-50. - Publication Year :
- 2001
-
Abstract
- A 37 amino acid cyclic polypeptide has been isolated from the organic extract of the tropical tree Palicourea condensata. Palicourein (1) is the largest of a growing family of plant peptides that contain a cyclized amino acid backbone cross-linked via three internal disulfide bridges. Palicourein inhibits the in vitro cytopathic effects of HIV-1RF infection of CEM-SS cells with an EC50 value of 0.1 microM and an IC50 value of 1.5 microM.
- Subjects :
- Amino Acid Sequence
Anti-HIV Agents chemistry
Anti-HIV Agents pharmacology
Cells, Cultured
Chromatography, High Pressure Liquid
Cytopathogenic Effect, Viral drug effects
Disulfides analysis
Humans
Molecular Sequence Data
Peptides, Cyclic chemistry
Peptides, Cyclic pharmacology
Protein Conformation
Trees chemistry
Anti-HIV Agents isolation & purification
Cyclotides
Peptides, Cyclic isolation & purification
Rubiaceae chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 0163-3864
- Volume :
- 64
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal of natural products
- Publication Type :
- Academic Journal
- Accession number :
- 11430013
- Full Text :
- https://doi.org/10.1021/np000372l