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The impact of highly active antiretroviral therapy on HIV-specific immune function.
- Source :
-
AIDS (London, England) [AIDS] 2001 Feb; Vol. 15 Suppl 2, pp. S4-10. - Publication Year :
- 2001
-
Abstract
- Highly active antiretroviral therapy (HAART) can suppress HIV type 1 plasma viremia to undetectable levels for up to 3 years or more. When the therapy is discontinued, viral rebound occurs in a majority of patients, indicating that HAART is unable to completely eradicate the virus. Initial calculations of the half-lives of the infected cells (estimated to be 14-21 days) suggested that only 3 years continuous HAART therapy would be necessary to achieve complete eradication; however, several studies have determined that the half-lives of chronically infected cells are in the order of 6-44 months. New estimates indicate that it may take as long as 60 years to eradicate the virus. Thus, there has been movement toward combining HAART with various means of augmenting and/or reconstituting the host's immune system, especially HIV-1-specific immune responses. The long-term goal is to discontinue HAART and permit the reconstituted immune system to contain whatever small amounts of the virus remain.
- Subjects :
- Acquired Immunodeficiency Syndrome drug therapy
Acquired Immunodeficiency Syndrome virology
CD4 Lymphocyte Count
CD4-Positive T-Lymphocytes immunology
CD4-Positive T-Lymphocytes virology
Humans
Viremia immunology
Acquired Immunodeficiency Syndrome immunology
Anti-HIV Agents pharmacology
Antiretroviral Therapy, Highly Active methods
HIV-1 growth & development
Immunotherapy methods
Subjects
Details
- Language :
- English
- ISSN :
- 0269-9370
- Volume :
- 15 Suppl 2
- Database :
- MEDLINE
- Journal :
- AIDS (London, England)
- Publication Type :
- Academic Journal
- Accession number :
- 11424976
- Full Text :
- https://doi.org/10.1097/00002030-200102002-00002