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Fc gamma RIII mediates neutrophil recruitment to immune complexes. a mechanism for neutrophil accumulation in immune-mediated inflammation.
- Source :
-
Immunity [Immunity] 2001 Jun; Vol. 14 (6), pp. 693-704. - Publication Year :
- 2001
-
Abstract
- Neutrophil accumulation is a hallmark of immune complex-mediated inflammatory disorders. Current models of neutrophil recruitment envision the capture of circulating neutrophils by activated endothelial cells. We now demonstrate that immobilized immune complexes alone support the rapid attachment of neutrophils, under physiologic flow conditions. Initial cell tethering requires the low-affinity Fc gamma receptor IIIB (Fc gamma RIIIB), and the beta(2) integrins are additionally required for the subsequent shear-resistant adhesion. The attachment function of Fc gamma RIIIB may be facilitated by its observed presentation on neutrophil microvilli. In vivo, in a model of acute antiglomerular basement membrane nephritis in which immune complexes are accessible to circulating neutrophils, Fc gamma RIII-deficient mice had a significant reduction in neutrophil recruitment. Thus, the interaction of immune complexes with Fc gamma RIII may mediate early neutrophil recruitment in immune complex-mediated inflammation.
- Subjects :
- Animals
Antibodies immunology
Antigens, CD genetics
Autoantibodies
Basement Membrane immunology
CD18 Antigens immunology
Cell Adhesion
GPI-Linked Proteins
Humans
K562 Cells
Kidney Glomerulus immunology
Leukocytes, Mononuclear cytology
Leukocytes, Mononuclear immunology
Macrophage-1 Antigen immunology
Mice
Mice, Inbred C57BL
Mice, Knockout
Microvilli immunology
Neutrophils physiology
Receptors, IgG genetics
Anti-Glomerular Basement Membrane Disease immunology
Antigen-Antibody Complex immunology
Antigens, CD immunology
Neutrophils immunology
Receptors, IgG immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1074-7613
- Volume :
- 14
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Immunity
- Publication Type :
- Academic Journal
- Accession number :
- 11420040
- Full Text :
- https://doi.org/10.1016/s1074-7613(01)00150-9