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Congenital monoblastic leukemia with 9;11 translocation in monozygotic twins : a case report.
- Source :
-
Journal of Korean medical science [J Korean Med Sci] 2001 Jun; Vol. 16 (3), pp. 366-70. - Publication Year :
- 2001
-
Abstract
- We report an autopsy case of congenital monoblastic leukemia that developed in monozygotic twins. The twin presented with progressive hepatosplenomegaly at 4 weeks after birth. One twin died of massive bleeding and hypovolemic shock before the treatment started. At autopsy, the liver was diffusely enlarged and showed a diffuse whitish discoloration except for the subcapsular and perivenular areas. Microscopic examination disclosed infiltration of histiocyte-like atypical cells along the sinusoids and portal areas of the liver. Spleen, lymph nodes and choroid plexus were also infiltrated by the tumor cells. However, bone marrow involvement of the tumor was minimal although multifocal. On immunohistochemical staining, these atypical cells were reactive for CD68 (PGM-1) and lysozyme, suggesting that the tumor cells might have been derived from mono- histiocyte. Cytogenetic study revealed 9;11 translocation, which is frequently associated with acute monoblastic leukemia. To the best of our knowledge, this is the first report of congenital monoblastic leukemia of monozygotic twins in Korea.
- Subjects :
- Fatal Outcome
Female
Hepatomegaly complications
Hepatomegaly genetics
Hepatomegaly pathology
Humans
Infant, Newborn
Leukemia, Monocytic, Acute complications
Leukemia, Monocytic, Acute genetics
Leukemia, Monocytic, Acute pathology
Liver pathology
Splenomegaly complications
Splenomegaly genetics
Splenomegaly pathology
Chromosomes, Human, Pair 11
Chromosomes, Human, Pair 9
Diseases in Twins genetics
Leukemia, Monocytic, Acute congenital
Translocation, Genetic
Twins, Monozygotic genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1011-8934
- Volume :
- 16
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of Korean medical science
- Publication Type :
- Academic Journal
- Accession number :
- 11410703
- Full Text :
- https://doi.org/10.3346/jkms.2001.16.3.366