Back to Search
Start Over
Dual control of hydrogen cyanide biosynthesis by the global activator GacA in Pseudomonas aeruginosa PAO1.
- Source :
-
FEMS microbiology letters [FEMS Microbiol Lett] 2001 Jun 12; Vol. 200 (1), pp. 73-8. - Publication Year :
- 2001
-
Abstract
- The global response regulator GacA of Pseudomonas aeruginosa PAO1 positively controls the production of the quorum sensing signal molecule N-butanoyl-homoserine-lactone (C4-HSL) and hence the synthesis of several C4-HSL-dependent virulence factors, including hydrogen cyanide (HCN). This study presents evidence that GacA positively influences the transcription of the rhlI gene, specifying C4-HSL synthase, explaining the quorum sensing-dependent transcriptional control of the HCN biosynthetic genes (hcnABC). In addition, GacA was found to modulate hcn gene expression positively at a post-transcriptional level involving the hcnA ribosome-binding site. Thus, the activating effect of GacA on cyanogenesis results from both transcriptional and post-transcriptional mechanisms.
- Subjects :
- 4-Butyrolactone analogs & derivatives
4-Butyrolactone biosynthesis
Bacterial Proteins genetics
Gene Expression Regulation, Bacterial
Multienzyme Complexes biosynthesis
Oxidoreductases biosynthesis
Oxidoreductases Acting on CH-NH2 Group Donors
Pseudomonas aeruginosa enzymology
RNA Processing, Post-Transcriptional
4-Butyrolactone genetics
Bacterial Proteins metabolism
Hydrogen Cyanide metabolism
Multienzyme Complexes genetics
Oxidoreductases genetics
Pseudomonas aeruginosa genetics
Subjects
Details
- Language :
- English
- ISSN :
- 0378-1097
- Volume :
- 200
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- FEMS microbiology letters
- Publication Type :
- Academic Journal
- Accession number :
- 11410352
- Full Text :
- https://doi.org/10.1111/j.1574-6968.2001.tb10695.x