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Multiple gestations in assisted reproductive technology: can they be avoided with blastocyst transfers?
- Source :
-
American journal of obstetrics and gynecology [Am J Obstet Gynecol] 2001 Jun; Vol. 184 (7), pp. 1471-5; discussion 1475-7. - Publication Year :
- 2001
-
Abstract
- Objective: Blastocysts are advanced-stage embryos with high implantation potential; theoretically, limited numbers of blastocysts can be used for embryo transfer to achieve good pregnancy rates with low multiple pregnancy rates. Clinical outcomes of a newly implemented blastocyst transfer program were evaluated.<br />Study Design: This study is a retrospective analysis of 553 blastocyst transfer cycles performed by a university-based in vitro fertilization program; risk factors associated with multiple gestations were analyzed.<br />Results: An average of 2.2 embryos were used for embryo transfer. The overall clinical pregnancy rate per embryo transfer was 45.1%; multiple gestation, twin, and triplet rates were 40.9%, 36.5%, and 4.3%, respectively. Multiple gestations increased significantly (1) when embryo transfer was done on day 5, (2) when > or =2 blastocysts were present on day 5, and (3) when maternal age was < or =30 years.<br />Conclusion: In spite of a conservative approach to the number of blastocysts used for embryo transfer, the overall multiple pregnancy rate was high, and triplet pregnancies did occur.
- Subjects :
- Blastocyst
Female
Humans
Maternal Age
Pregnancy
Pregnancy Rate
Retrospective Studies
Risk Factors
Time Factors
Triplets statistics & numerical data
Twins statistics & numerical data
Embryo Transfer methods
Pregnancy, Multiple statistics & numerical data
Reproductive Techniques adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 0002-9378
- Volume :
- 184
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- American journal of obstetrics and gynecology
- Publication Type :
- Academic Journal
- Accession number :
- 11408870
- Full Text :
- https://doi.org/10.1067/mob.2001.114851