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Using isoproterenol stress echocardiography to predict the response to carvedilol in patients with dilated cardiomyopathy.
- Source :
-
Japanese circulation journal [Jpn Circ J] 2001 Jun; Vol. 65 (6), pp. 514-8. - Publication Year :
- 2001
-
Abstract
- Trials have demonstrated that carvedilol can produce hemodynamic, symptomatic, and prognostic improvements in dilated cardiomyopathy (DCM), but some DCM patients have deteriorated after carvedilol, developing congestive heart failure. The present study investigated the use of isoproterenol (ISP) stress echocardiography to select those patients with DCM who would respond to carvedilol. ISP was infused intravenously in 22 patients with DCM and they were classified into 2 groups based on the left ventricular systolic response: good response to ISP [change in fractional shortening (FS) with ISP > 0.05, n=13] and poor response to ISP (change < or = 0.05, n=9). In the good response group, FS significantly increased from 0.12+/-0.04 to 0.17+/-0.08 (mean+/-SD, p<0.05) with carvedilol, and 7 patients improved symptomatically (New York Heart Association class). However, in the poor response group, no significant difference was observed between FS at baseline and that at the end of follow-up. Moreover, only 1 patient in the poor response group improved symptomatically. ISP stress echocardiography can assist in selecting patients with DCM who will respond positively to carvedilol.
- Subjects :
- Adult
Aged
Carbazoles adverse effects
Cardiomyopathy, Dilated complications
Cardiomyopathy, Dilated diagnosis
Carvedilol
Contraindications
Echocardiography methods
Female
Follow-Up Studies
Heart Function Tests methods
Hemodynamics drug effects
Humans
Male
Middle Aged
Prognosis
Propanolamines adverse effects
Treatment Outcome
Adrenergic beta-Antagonists administration & dosage
Carbazoles administration & dosage
Cardiomyopathy, Dilated drug therapy
Echocardiography drug effects
Isoproterenol pharmacology
Propanolamines administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 0047-1828
- Volume :
- 65
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Japanese circulation journal
- Publication Type :
- Academic Journal
- Accession number :
- 11407733
- Full Text :
- https://doi.org/10.1253/jcj.65.514