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Vesiculopustular eruptions in Down syndrome neonates with myeloproliferative disorders.
- Source :
-
Archives of dermatology [Arch Dermatol] 2001 Jun; Vol. 137 (6), pp. 760-3. - Publication Year :
- 2001
-
Abstract
- Background: Infants with Down syndrome are at increased risk for hematologic abnormalities, including leukemoid reaction, transient myeloproliferative disorder, and congenital leukemia. The differential diagnosis of a vesiculopustular eruption in an infant with Down syndrome and these hematologic abnormalities is broad and includes benign, self-limited disorders as well as life-threatening infections.<br />Observation: We describe 3 newborns with Down syndrome and vesiculopustular eruptions associated with myeloproliferative disorders during the neonatal period. These lesions differ from other neonatal vesicular eruptions in that they have a unique distribution, display pathergy, and contain immature hematopoietic cells similar to circulating blast cells. Resolution occurs without treatment as the hematologic disorder subsides.<br />Conclusions: Infants with Down syndrome and hematologic abnormalities may have a cutaneous eruption that has characteristic clinical and histopathologic findings. It is possible that this eruption has been unrecognized in the past because of its self-limited course. Whether this eruption is a prognostic factor for the subsequent development of leukemia is uncertain.
- Subjects :
- Diagnosis, Differential
Facial Dermatoses complications
Facial Dermatoses pathology
Fatal Outcome
Female
Humans
Infant, Newborn
Male
Skin Diseases, Vesiculobullous complications
Skin Diseases, Vesiculobullous pathology
Down Syndrome complications
Facial Dermatoses diagnosis
Leukemia, Myeloid, Acute complications
Skin Diseases, Vesiculobullous diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 0003-987X
- Volume :
- 137
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Archives of dermatology
- Publication Type :
- Academic Journal
- Accession number :
- 11405767