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Vesiculopustular eruptions in Down syndrome neonates with myeloproliferative disorders.

Authors :
Nijhawan A
Baselga E
Gonzalez-Ensenat MA
Vicente A
Southern JF
Camitta BM
Esterly NB
Drolet BA
Source :
Archives of dermatology [Arch Dermatol] 2001 Jun; Vol. 137 (6), pp. 760-3.
Publication Year :
2001

Abstract

Background: Infants with Down syndrome are at increased risk for hematologic abnormalities, including leukemoid reaction, transient myeloproliferative disorder, and congenital leukemia. The differential diagnosis of a vesiculopustular eruption in an infant with Down syndrome and these hematologic abnormalities is broad and includes benign, self-limited disorders as well as life-threatening infections.<br />Observation: We describe 3 newborns with Down syndrome and vesiculopustular eruptions associated with myeloproliferative disorders during the neonatal period. These lesions differ from other neonatal vesicular eruptions in that they have a unique distribution, display pathergy, and contain immature hematopoietic cells similar to circulating blast cells. Resolution occurs without treatment as the hematologic disorder subsides.<br />Conclusions: Infants with Down syndrome and hematologic abnormalities may have a cutaneous eruption that has characteristic clinical and histopathologic findings. It is possible that this eruption has been unrecognized in the past because of its self-limited course. Whether this eruption is a prognostic factor for the subsequent development of leukemia is uncertain.

Details

Language :
English
ISSN :
0003-987X
Volume :
137
Issue :
6
Database :
MEDLINE
Journal :
Archives of dermatology
Publication Type :
Academic Journal
Accession number :
11405767