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[Chromophobe cell renal cancer, a distinct entity. Report of a series of 35 cases].
- Source :
-
Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie [Prog Urol] 2001 Apr; Vol. 11 (2), pp. 209-14; discussion 214-6. - Publication Year :
- 2001
-
Abstract
- Objective: To describe the clinical and histological characteristics and natural history of clear cell renal carcinoma.<br />Patients and Methods: The case files of 35 patients (22 men and 13 women, with a mean age of 58 +/- 13.8 years) operated for clear cell renal carcinoma were reviewed. The circumstances of diagnosis and the histological features of the tumour were analysed. The outcome of the patients was studied with a mean follow-up of 70 +/- 20.2 months.<br />Results: The diagnosis was incidental in 66% of cases. The macroscopic appearance of the tumour was characteristic: homogeneous and beige or white colour. On light microscopy, tumours were composed of variable proportions of clear cells and eosinophilic cells. The were classified as 15 predominantly eosinophilic tumours (43%), 9 predominantly clear cell tumours (26%) and 11 tumours composed of equal number of clear cells and eosinophilic cells (31%). Nuclei were irregular and indented. Hale stain was positive in every case. The majority of tumours were confined to the kidney (T1: 65% and T2: 29%) with a low nuclear grade (91% of grades 1 and 2). No patient developed local recurrence or metastasis during follow-up. The overall 5-year survival rate was 92%. No death related to the disease was reported.<br />Conclusion: The histological diagnosis of clear cell renal cancer is now easy and can be suggested even on macroscopic examination of the operative specimen. This tumour appears to have a good prognosis, as it is usually confined to the kidney with a low nuclear grade.
Details
- Language :
- French
- ISSN :
- 1166-7087
- Volume :
- 11
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie
- Publication Type :
- Academic Journal
- Accession number :
- 11400480