Back to Search
Start Over
Ranitidine bismuth citrate-based triple therapy for seven days, with or without further anti-secretory therapy, is highly effective in patients with duodenal ulcer and Helicobacter pylori infection.
- Source :
-
European journal of gastroenterology & hepatology [Eur J Gastroenterol Hepatol] 2001 May; Vol. 13 (5), pp. 547-50. - Publication Year :
- 2001
-
Abstract
- Objective: To compare the efficacy of two protocols for the eradication of Helicobacter pylori infection and the healing of active duodenal ulcer: (i) ranitidine bismuth citrate (RBC) plus two antibiotics for 7 days, and (ii) the same triple therapy followed by 3 weeks of anti-secretory drug treatment.<br />Methods: The study comprised 102 patients with active duodenal ulcer and H. pylori infection; the patients were randomized to open treatment with either RBC 400 mg b.d. plus amoxycillin 1 g b.d. and clarithromycin 500 mg b.d. for 7 days, or the same treatment followed by 3 weeks of RBC 400 mg b.d. alone. Ulcer healing was confirmed by endoscopy. H. pylori eradication was assessed by endoscopy, rapid urease test and histology.<br />Results: The ulcer healed in 48/50 patients on RBC-based triple therapy alone (96.0%) and in 51/52 patients on triple therapy plus further anti-secretory treatment (98.1%). On an intention-to-treat basis, H. pylori had been successfully eradicated in 42/50 patients on triple therapy (84.0%) and in 44/52 patients on triple therapy plus anti-secretory treatment (84.6%), while by per protocol analysis the H. pylori eradication rates were 91.3% (42/46) and 89.8% (44/49), respectively.<br />Conclusions: One-week triple therapy with RBC, amoxycillin and clarithromycin is highly effective in eradicating H. pylori and healing duodenal ulcers, even if not followed by anti-secretory drug treatment.
- Subjects :
- Adult
Aged
Aged, 80 and over
Amoxicillin therapeutic use
Antacids therapeutic use
Clarithromycin therapeutic use
Clinical Protocols
Drug Administration Schedule
Drug Therapy, Combination
Duodenal Ulcer microbiology
Duodenoscopy
Female
Helicobacter Infections microbiology
Histamine H2 Antagonists therapeutic use
Humans
Male
Middle Aged
Sucralfate therapeutic use
Treatment Outcome
Anti-Bacterial Agents therapeutic use
Anti-Ulcer Agents therapeutic use
Duodenal Ulcer drug therapy
Helicobacter Infections drug therapy
Helicobacter pylori isolation & purification
Organometallic Compounds therapeutic use
Ranitidine therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 0954-691X
- Volume :
- 13
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- European journal of gastroenterology & hepatology
- Publication Type :
- Academic Journal
- Accession number :
- 11396535
- Full Text :
- https://doi.org/10.1097/00042737-200105000-00014