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Thiazole analogues of the NSAID indomethacin as selective COX-2 inhibitors.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2001 May 21; Vol. 11 (10), pp. 1325-8. - Publication Year :
- 2001
-
Abstract
- The carboxyl group of the NSAID indomethacin was replaced with a variety of substituted thiazoles to obtain a series of potent, selective inhibitors of COX-2. Additional substitutions were made at the 1-position and 5-position of the indole of indomethacin.
- Subjects :
- Anti-Inflammatory Agents, Non-Steroidal pharmacology
Cyclooxygenase 2
Cyclooxygenase 2 Inhibitors
Cyclooxygenase Inhibitors pharmacology
Humans
Indomethacin chemical synthesis
Indomethacin pharmacology
Inhibitory Concentration 50
Isoenzymes drug effects
Membrane Proteins
Prostaglandin-Endoperoxide Synthases drug effects
Structure-Activity Relationship
Thiazoles chemical synthesis
Anti-Inflammatory Agents, Non-Steroidal chemical synthesis
Cyclooxygenase Inhibitors chemical synthesis
Indomethacin analogs & derivatives
Isoenzymes metabolism
Prostaglandin-Endoperoxide Synthases metabolism
Thiazoles pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0960-894X
- Volume :
- 11
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 11392547
- Full Text :
- https://doi.org/10.1016/s0960-894x(01)00212-8