Peptidergic correction of the effect of acute hypobaric hypoxia in pregnant rats on progeny.

Authors :: Maslova MV
Zemlyanskii KS
Shkol'nikova MV
Maklakova AS
Krushinskaya YV
Sokolova NA
Ashmarin IP
Source :: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2001 Feb; Vol. 131 (2), pp. 109-12.
Publication Year :: 2001
Abstract: Acute hypobaric hypoxia of pregnant rats led to a significant delay in body weight gain, growth and time of eye opening in newborn rat pups which was paralleled by behavioral changes. Preventive intranasal instillations of peptide mixture (semax and beta-casomorphine-7) to pregnant females prevented the effect of hypoxia on the progeny.

Subjects :: Analgesics, Opioid pharmacology
Animals
Animals, Newborn
Body Weight
Female
Fetal Hypoxia physiopathology
Male
Maze Learning drug effects
Neuroprotective Agents pharmacology
Pregnancy
Rats
Receptors, Opioid, mu agonists
Adrenocorticotropic Hormone analogs & derivatives
Adrenocorticotropic Hormone pharmacology
Behavior, Animal physiology
Endorphins pharmacology
Fetal Hypoxia drug therapy
Hypoxia physiopathology
Peptide Fragments pharmacology

Full Text Access

Tools