Back to Search
Start Over
[Participation of various types of serotonin receptors in the regulation of drinking behavior and salt appetite in rats].
- Source :
-
Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova [Ross Fiziol Zh Im I M Sechenova] 2001 Mar; Vol. 87 (3), pp. 360-8. - Publication Year :
- 2001
-
Abstract
- The 5-HT1A agonist 8-OH-DPAT was shown to diminish the water and 1.8% NaCl solution consumption, whereas its antagonist pMPPI--to enhance the water intake in rats. Another agonist: CGS-12066A enhanced water intake or exerted no effect on drinking behaviour and diminished salt intake. Other substances under study exerted various effects. The data obtained suggest that the 5-HT receptors are involved in regulation of water and salt intake, even though the mechanisms of the effects are different. Apparently 5-HT1B and 5-HT2A receptors play an activating role in regulation of water intake, whereas 5-HT1A, 5-HT2C and 5-HT3 receptors act as inhibitory ones. Only three of the receptors under study seem to regulate salt intake by inhibiting the salt appetite.
- Subjects :
- Animals
Appetite Regulation drug effects
Drinking
Drinking Behavior drug effects
Male
Rats
Rats, Wistar
Receptor, Serotonin, 5-HT1B
Receptor, Serotonin, 5-HT2A
Receptor, Serotonin, 5-HT2C
Receptors, Serotonin drug effects
Receptors, Serotonin, 5-HT1
Receptors, Serotonin, 5-HT3
Serotonin Antagonists pharmacology
Serotonin Receptor Agonists pharmacology
Appetite Regulation physiology
Drinking Behavior physiology
Receptors, Serotonin physiology
Sodium Chloride, Dietary
Subjects
Details
- Language :
- Russian
- ISSN :
- 0869-8139
- Volume :
- 87
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova
- Publication Type :
- Academic Journal
- Accession number :
- 11386160