Back to Search
Start Over
Vertebrate model systems in the study of early heart development: Xenopus and zebrafish.
- Source :
-
American journal of medical genetics [Am J Med Genet] 2000 Winter; Vol. 97 (4), pp. 248-57. - Publication Year :
- 2000
-
Abstract
- Xenopus and zebrafish serve as outstanding models in which to study vertebrate heart development. The embryos are transparent, allowing observation during organogenesis; they can be obtained in large numbers; and they are readily accessible to embryologic manipulation and microinjection of RNA, DNA, or protein. These embryos can live by diffusion for several days, allowing analysis of mutants or experimental treatments that perturb normal heart development. Xenopus embryos have been used to understand the induction of the cardiac field, the role of Nkx genes in cardiac development, and the role transforming growth factor beta molecules in the establishment and signaling of left-right axis information. Large-scale mutant screens in zebrafish and the development of transgenics in both Xenopus and zebrafish have accelerated the molecular identification of genes that regulate conserved steps in cardiovascular development.
- Subjects :
- Animals
Drosophila melanogaster embryology
Drosophila melanogaster genetics
Embryo, Nonmammalian physiology
Female
Gene Targeting methods
Genetic Techniques
Genome
Glycoproteins genetics
Glycoproteins physiology
Heart Defects, Congenital embryology
Heart Defects, Congenital genetics
Homeobox Protein Nkx-2.5
Homeodomain Proteins genetics
Homeodomain Proteins physiology
Humans
Intracellular Signaling Peptides and Proteins
Male
Models, Biological
Morphogenesis
Repressor Proteins genetics
Repressor Proteins physiology
Species Specificity
Trans-Activators genetics
Trans-Activators physiology
Transforming Growth Factor beta deficiency
Transforming Growth Factor beta genetics
Transforming Growth Factor beta physiology
Vertebrates genetics
Xenopus laevis embryology
Xenopus laevis genetics
Zebrafish embryology
Zebrafish genetics
Zebrafish Proteins
Drosophila Proteins
Heart embryology
Models, Animal
Transcription Factors
Vertebrates embryology
Xenopus Proteins
Subjects
Details
- Language :
- English
- ISSN :
- 0148-7299
- Volume :
- 97
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- American journal of medical genetics
- Publication Type :
- Academic Journal
- Accession number :
- 11376436
- Full Text :
- https://doi.org/10.1002/1096-8628(200024)97:4<248::aid-ajmg1275>3.0.co;2-c