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The collagen receptor DDR2 regulates proliferation and its elimination leads to dwarfism.
- Source :
-
EMBO reports [EMBO Rep] 2001 May; Vol. 2 (5), pp. 446-52. - Publication Year :
- 2001
-
Abstract
- The discoidin domain receptor 2 (DDR2) is a member of a subfamily of receptor tyrosine kinases whose ligands are fibrillar collagens, and is widely expressed in postnatal tissues. We have generated DDR2-deficient mice to establish the in vivo functions of this receptor, which have remained obscure. These mice exhibit dwarfism and shortening of long bones. This phenotype appears to be caused by reduced chondrocyte proliferation, rather than aberrant differentiation or function. In a skin wound healing model, DDR2-/- mice exhibit a reduced proliferative response compared with wild-type littermates. In vitro, fibroblasts derived from DDR2-/- mutants proliferate more slowly than wild-type fibroblasts, a defect that is rescued by introduction of wild-type but not kinase-dead DDR2 receptor. Together our results suggest that DDR2 acts as an extracellular matrix sensor to modulate cell proliferation.
- Subjects :
- Animals
Apoptosis
Bone Development genetics
Chondrocytes metabolism
Collagen genetics
Collagen metabolism
Discoidin Domain Receptors
Dwarfism physiopathology
Fibroblasts metabolism
Growth Plate anatomy & histology
Humerus growth & development
Immunoblotting
In Situ Hybridization
In Situ Nick-End Labeling
Metatarsal Bones growth & development
Mice
Mice, Knockout
Receptor Protein-Tyrosine Kinases genetics
Receptor Protein-Tyrosine Kinases metabolism
Receptors, Mitogen genetics
Skin cytology
Skin injuries
Skin metabolism
Tibia growth & development
Wound Healing
Bone Development physiology
Cell Division
Chondrocytes physiology
Dwarfism genetics
Fibroblasts physiology
Receptors, Mitogen metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1469-221X
- Volume :
- 2
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- EMBO reports
- Publication Type :
- Academic Journal
- Accession number :
- 11375938
- Full Text :
- https://doi.org/10.1093/embo-reports/kve094