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Immunohistochemical evaluation of cathepsin D expression in colorectal cancer.
- Source :
-
Folia histochemica et cytobiologica [Folia Histochem Cytobiol] 2001; Vol. 39 (2), pp. 153-4. - Publication Year :
- 2001
-
Abstract
- Cathepsin D is one of the main proteolytic enzymes contributing to the development of cancer. The aim of the present study was to evaluate the expression of cathepsin D in 48 colorectal adenocarcinomas at pT3 stage of clinical advancement and G2 histologic grade. The correlation between cathepsin D expression, anatomo-clinical advancement and the presence of chosen anatomo-clinical properties of the tumours was also analysed. Formalin-fixed and paraffin-embedded tissues were investigated with anti-cathepsin D antibody. Immunolocalisation of cathepsin D was performed using Labelled Streptavidin Biotin (LSAB) method. A statistical correlation was found between high catepsin D expression in the cells of the main mass of the cancer and low cathepsin D expression in low-differentiated cancer cells which formed nests at the border of cancer invasion. There was no correlation between cathepsin D expression in the cells of colorectal cancer and other anatomo-clinical parameters of the tumours.
Details
- Language :
- English
- ISSN :
- 0239-8508
- Volume :
- 39
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Folia histochemica et cytobiologica
- Publication Type :
- Academic Journal
- Accession number :
- 11374801