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Human infection from an unidentified erythrocyte-associated bacterium.
- Source :
-
The New England journal of medicine [N Engl J Med] 1979 Oct 25; Vol. 301 (17), pp. 897-900. - Publication Year :
- 1979
-
Abstract
- A 49-year-old splenectomized man had an infection from an unidentified, gram-positive, rod-shaped bacterium that adhered to the majority of his peripheral-blood erythrocytes. On transmission electron microscopy, the bacterium was seen to be extra-erythrocytic and was 0.2 micrometer wide by 1.0 to 1.7 micrometer long. It possessed a thick, granular cell wall, a trilamellar membrane external to the cell wall and prominent mesosomes. Attempts to cultivate the organism in vitro or to duplicate the patient's disease in splenectomized animals were unsuccessful. The patient's response suggested that the bacterium was susceptible to cell-wall-active antibiotics and to chloramphenicol but not to tetracycline. This bacterium may be the cause of other chronic, fever-producing, multisystem diseases of unknown origin.
- Subjects :
- Animals
Anti-Bacterial Agents therapeutic use
Bacteria growth & development
Bacteria ultrastructure
Bacterial Infections drug therapy
Chloramphenicol therapeutic use
Dogs
Erythrocyte Membrane microbiology
Guinea Pigs
Haplorhini
Humans
Male
Middle Aged
Rabbits
Rats
Sepsis microbiology
Bacterial Infections microbiology
Erythrocytes microbiology
Splenectomy
Subjects
Details
- Language :
- English
- ISSN :
- 0028-4793
- Volume :
- 301
- Issue :
- 17
- Database :
- MEDLINE
- Journal :
- The New England journal of medicine
- Publication Type :
- Academic Journal
- Accession number :
- 113680
- Full Text :
- https://doi.org/10.1056/NEJM197910253011701