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Specific immunotherapy.
- Source :
-
British medical bulletin [Br Med Bull] 2000; Vol. 56 (4), pp. 1019-36. - Publication Year :
- 2000
-
Abstract
- The prevalence of atopic allergic disease increased substantially towards the end of the 20th century and is set to rise further. This group of diseases now constitutes the most common cause of chronic ill health in industrialised countries. Despite considerable attention from the pharmaceutical industry, little progress has been made in the development of disease-modifying therapies. In contrast, recent activity has focused almost exclusively on treatment of symptoms (palliation) rather than cause. The failure of palliative approaches to address the issue of increasing incidence of disease is in evidence in the case of allergic diseases and is a continuing focus of concern. At present, the most frequently employed non-palliative form of disease-modifying therapy is specific allergen immunotherapy (SIT) in which increasing doses of whole allergen extract are administered in increasing dose in order to desensitise the allergic subject.
- Subjects :
- Allergens genetics
Allergens immunology
Animals
Bronchial Provocation Tests
Clonal Anergy
Humans
Hypersensitivity diagnosis
Hypersensitivity immunology
Immunoglobulin E immunology
Peptide Fragments administration & dosage
Poaceae
Pollen
Protein Isoforms therapeutic use
Recombinant Proteins immunology
Recombinant Proteins therapeutic use
Rhinitis, Allergic, Seasonal therapy
Th1 Cells immunology
Th2 Cells immunology
Vaccines, DNA administration & dosage
Allergens administration & dosage
Desensitization, Immunologic methods
Hypersensitivity therapy
Subjects
Details
- Language :
- English
- ISSN :
- 0007-1420
- Volume :
- 56
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- British medical bulletin
- Publication Type :
- Academic Journal
- Accession number :
- 11359635
- Full Text :
- https://doi.org/10.1258/0007142001903517