Back to Search
Start Over
Ethnic differences in lipid metabolism in two groups of obese South African women.
- Source :
-
Journal of lipid research [J Lipid Res] 2001 May; Vol. 42 (5), pp. 760-7. - Publication Year :
- 2001
-
Abstract
- There is a higher prevalence of ischemic heart disease (IHD) in South African white than black women. The objective of this study was to determine biochemical explanations for this prevalence. The study group contained 15 obese black women (OBW) and 14 obese white women (OWW), all premenopausal, who were examined after an overnight fast. Anthropometric measurements and blood concentrations of glucose, non-esterified fatty acids (NEFAs), catecholamines, plasminogen activator inhibitor-1, C-peptide, proinsulin, lipograms, cortisol, growth hormone, and post-heparin lipoprotein lipase activity were measured during an oral glucose tolerance test (OGTT). Body composition was measured using bioelectrical impedance analysis, and subcutaneous and visceral fat mass were assessed with CT-scans. Visceral fat area was higher in OWW (139.7 +/- 10.7 cm(2)) than in OBW (72.3 +/- 3.9 cm(2)) (P < 0.01), as were fasting and 3 h triglyceride concentrations (P < 0.05 for all). OWW also had higher NEFA levels than OBW at 3 and 4 h compared with OBW (P < 0.05 for both). Fasting cortisol (266 +/- 24 vs. 197 +/- 19 nmol/l; P < 0.05) was higher in OWW than in OBW. These data demonstrate that OWW have higher visceral fat mass than OBW, which may lead to a more atherogenic fasting and postprandial lipid profile. The higher cortisol levels of the OWW may promote visceral fat deposition.
- Subjects :
- Adult
Area Under Curve
Blood Glucose metabolism
Body Composition
C-Peptide blood
C-Peptide metabolism
Fatty Acids, Nonesterified metabolism
Female
Glucose Tolerance Test
Human Growth Hormone blood
Humans
Hydrocortisone blood
Insulin blood
Lipids blood
Middle Aged
South Africa
Tomography, X-Ray Computed
Black People
Body Mass Index
Lipid Metabolism
Myocardial Ischemia etiology
Obesity ethnology
Obesity metabolism
White People
Subjects
Details
- Language :
- English
- ISSN :
- 0022-2275
- Volume :
- 42
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Journal of lipid research
- Publication Type :
- Academic Journal
- Accession number :
- 11352983