Back to Search
Start Over
The influence of L-arginine on heart rate and tissue oxygen extraction in haemorrhaged rabbits.
- Source :
-
Pharmacological research [Pharmacol Res] 2001 Apr; Vol. 43 (4), pp. 321-7. - Publication Year :
- 2001
-
Abstract
- Several studies have already indicated some beneficial effects of L-arginine in haemorrhaged rats. The aim of our study was to assess whether intravenous bolus injection of L-arginine could improve some cardiovascular and metabolic parameters in anaesthetized haemorrhaged rabbits (intermittent bleeding; 40% of the estimated blood volume for 15 min). I.v. bolus injection of L-arginine ( 300 mg kg(-1)--L-Arg(300)) increased heart rate (app. 10%) and decreased venous haemoglobin saturation with oxygen (sO(2)) (app. 23%) 60 min after the cessation of bleeding, without changes in arterial pressure. D-arginine (300 mg kg(-1)i.v. bolus-D-Arg(300)) produced similar, but insignificant haemodynamic and metabolic changes. In addition, no difference was found between the effects of the L- and D-isomers. Accordingly, L-arginine produces beneficial effects on the heart rate and tissue oxygen extraction in haemorrhaged rabbits. However, such changes do not appear to be stereospecific.<br /> (Copyright 2001 Academic Press.)
- Subjects :
- Acid-Base Equilibrium drug effects
Animals
Arginine administration & dosage
Arginine chemistry
Arginine therapeutic use
Blood Proteins analysis
Hematocrit
Hemoglobins metabolism
Hemorrhage drug therapy
Monitoring, Physiologic
Rabbits
Stereoisomerism
Survival Rate
Water-Electrolyte Balance drug effects
Arginine pharmacology
Blood Pressure drug effects
Heart Rate drug effects
Hemorrhage metabolism
Oxygen metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1043-6618
- Volume :
- 43
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Pharmacological research
- Publication Type :
- Academic Journal
- Accession number :
- 11352536
- Full Text :
- https://doi.org/10.1006/phrs.2001.0805