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Naturally occurring prostate cancer antigen-specific T cell responses of a Th1 phenotype can be detected in patients with prostate cancer.
- Source :
-
The Prostate [Prostate] 2001 May 15; Vol. 47 (3), pp. 222-9. - Publication Year :
- 2001
-
Abstract
- Background: Cytotoxic T cells (CTL) are considered one of the primary effector cell populations in antitumor immunity. Recent studies, however, have demonstrated the critical importance of helper T cells (Th), specifically interferon gamma (IFN gamma)-secreting Th1 cells, either by supporting an appropriate CTL environment or by recruiting other effector cells. We evaluated whether patients with prostate cancer have naturally occurring Th-cell responses specific for two prostate cancer-associated antigens, prostate-specific antigen (PSA) and prostatic acid phosphatase (PAP), and whether Th1-type responses to these antigens could be detected.<br />Methods: Peripheral blood mononuclear cells (PBMC) were collected from 80 patients with prostate cancer and 20 male controls without prostate disease. Th-cell responses were evaluated by measuring antigen-specific proliferation. IFN gamma and IL-5 secretion in response to antigen stimulation was determined by enzyme-linked immunosorbent assay.<br />Results: T cell proliferative responses specific for PSA and PAP could be detected in patients with prostate cancer. Six percent (5/80) of patients had T cell responses specific for PSA and 11% (9/80) for PAP. T cell responses specific for PSA were more prevalent in patients with metastatic disease (P = 0.02), whereas responses specific for PAP could be detected in patients irrespective of disease stage. IFN gamma-producing Th cells, specific for both PSA and PAP, could be identified in patients with prostate cancer.<br />Conclusions: Patients with prostate cancer can have detectable Th-cell responses specific for the prostate cancer-associated proteins PSA and PAP. The presence of antigen-specific Th1 immune responses in prostate cancer patients suggests that an immune environment capable of supporting antigen-specific CTL may exist in vivo. Prostate 47:222-229, 2001.<br /> (Copyright 2001 Wiley-Liss, Inc.)
- Subjects :
- Enzyme-Linked Immunosorbent Assay
Humans
Interferon-gamma blood
Interferon-gamma metabolism
Interleukin-5 blood
Interleukin-5 metabolism
Lymphocyte Activation immunology
Male
Middle Aged
Neoplasm Metastasis
Neoplasm Staging
Phenotype
Prostatic Neoplasms blood
Prostatic Neoplasms pathology
Th1 Cells metabolism
Acid Phosphatase immunology
Epitopes, T-Lymphocyte immunology
Prostate-Specific Antigen immunology
Prostatic Neoplasms immunology
Th1 Cells immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0270-4137
- Volume :
- 47
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- The Prostate
- Publication Type :
- Academic Journal
- Accession number :
- 11351352
- Full Text :
- https://doi.org/10.1002/pros.1066