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Clinical value of whole-body emission tomography in potentially curable colorectal liver metastases.
- Source :
-
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology [Eur J Surg Oncol] 2001 Mar; Vol. 27 (2), pp. 175-9. - Publication Year :
- 2001
-
Abstract
- Aims: In selected patients with colorectal liver metastases, hepatic resection offers an opportunity for cure, with a 25-38% 5-year survival rate. The aim of this prospective study was to evaluate whether patient selection could be improved with pre-operative whole-body 18-fluoro-2-deoxyglucose-positron emission tomography (FDG-PET) scan.<br />Methods: Ninety-one consecutive patients were considered to be eligible for liver resection after investigation with conventional diagnostic methods (CDM). In all these patients a whole-body PET scan with FDG was performed prior to surgery. Follow-up was complete with a mean of 23 months (2 weeks-92 months). All PET images were reviewed blinded to intraoperative and follow-up data.<br />Results: PET confirmed liver metastases in 90 (99%) patients, while it provided additional information in 10 (11%) patients, i.e., seven intra-abdominal, and three extra-abdominal. PET falsely upstaged six (6.6%) patients in whom malignancy was excluded by additional investigation, at the time of surgery, or during follow-up. PET falsely understaged seven (7.7%) patients with small intra-abdominal lesions.<br />Conclusion: In patients with potentially curable colorectal liver metastases according to conventional diagnostic methods, whole-body FDG-PET can be considered as a complementary examination in order to further select patients for potentially curative liver resection, and to optimize therapeutic strategy.
- Subjects :
- Adult
Aged
Diagnostic Errors
Female
Fluorodeoxyglucose F18
Humans
Liver Neoplasms surgery
Male
Middle Aged
Patient Selection
Prospective Studies
Radiopharmaceuticals
Sensitivity and Specificity
Survival Rate
Whole-Body Irradiation
Colorectal Neoplasms pathology
Liver Neoplasms diagnostic imaging
Liver Neoplasms secondary
Tomography, Emission-Computed methods
Subjects
Details
- Language :
- English
- ISSN :
- 0748-7983
- Volume :
- 27
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
- Publication Type :
- Academic Journal
- Accession number :
- 11345944
- Full Text :
- https://doi.org/10.1053/ejso.2000.1075