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Effects of parenteral administration of doramectin or a combination of ivermectin and clorsulon on control of gastrointestinal nematode and liver fluke infections and on growth performance in cattle.
- Source :
-
Journal of the American Veterinary Medical Association [J Am Vet Med Assoc] 2001 May 01; Vol. 218 (9), pp. 1465-8. - Publication Year :
- 2001
-
Abstract
- Objective: To compare effects of an injectable doramectin preparation with those of an injectable ivermectin-clorsulon preparation on control of gastrointestinal nematodes and liver flukes and on growth performance in cattle.<br />Design: Randomized complete block design.<br />Animals: 60 crossbred calves.<br />Procedures: Calves (20/treatment group) were treated with doramectin or ivermectin-clorsulon or were not treated. Fecal samples were collected for nematode and Fasciola hepatica egg counts on day 0 and for up to 140 days after treatment. Cattle were weighed before treatment and at 28-day intervals until day 140.<br />Results: From day 7 through day 49, nematode egg counts for calves treated with doramectin or with ivermectin-clorsulon were significantly lower than those for untreated control calves. As the study progressed beyond day 56, the percentages of cattle with fluke eggs in their feces increased, but differences in regard to these percentages were not detected among the 3 groups. Average daily gain for the doramectin-treated cattle (0.79 kg/d [1.74 lb/d]) was significantly greater than that for the cattle treated with ivermectin-clorsuIon (0.71 kg/d [1.56 lb/d]); values for both groups were significantly greater than that for the control cattle (0.62 kg/d [1.37 lb/d]).<br />Conclusions and Clinical Relevance: Results suggest that doramectin had a greater impact on subclinical gastrointestinal tract parasitism in calves, as demonstrated by growth performance, than did ivermectin-clorsulon. In the Gulf Coast region of the United States, spring-born nursing beef calves may have minimal grazing exposure to F hepatica during the peak fluke transmission period; therefore, mature fluke burdens may be negligible at the beginning of the fall season.
- Subjects :
- Animals
Anthelmintics administration & dosage
Cattle
Cattle Diseases parasitology
Drug Combinations
Fasciola hepatica drug effects
Fascioliasis drug therapy
Fascioliasis prevention & control
Feces parasitology
Gastrointestinal Diseases drug therapy
Gastrointestinal Diseases parasitology
Ivermectin administration & dosage
Ivermectin analogs & derivatives
Ivermectin therapeutic use
Male
Nematoda drug effects
Nematode Infections drug therapy
Nematode Infections prevention & control
Parasite Egg Count veterinary
Random Allocation
Seasons
Sulfanilamides administration & dosage
Sulfanilamides therapeutic use
Time Factors
Weight Gain drug effects
Anthelmintics therapeutic use
Cattle Diseases drug therapy
Fascioliasis veterinary
Gastrointestinal Diseases veterinary
Nematode Infections veterinary
Subjects
Details
- Language :
- English
- ISSN :
- 0003-1488
- Volume :
- 218
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Journal of the American Veterinary Medical Association
- Publication Type :
- Academic Journal
- Accession number :
- 11345312
- Full Text :
- https://doi.org/10.2460/javma.2001.218.1465