Back to Search
Start Over
Antiviral quinolinehydrazones. A modified Free-Wilson analysis.
- Source :
-
Journal of medicinal chemistry [J Med Chem] 1975 Mar; Vol. 18 (3), pp. 245-50. - Publication Year :
- 1975
-
Abstract
- Eighty-four 4-quinolinehydrazones were synthesized and tested for antiviral activity. Thirty nine derivatives were active against influenza A2 and/or Coxsackie B1 in mice at a dose of 25 mg/kg sc. Structure-activity relationships of 44 derivatives (21 inactive) were analyzed qualitatively using a modified Free-Wilson approach.
- Subjects :
- Animals
Antiviral Agents therapeutic use
Coxsackievirus Infections drug therapy
Herpes Simplex drug therapy
Hydrazones chemical synthesis
Hydrazones therapeutic use
Kinetics
Mice
Orthomyxoviridae Infections drug therapy
Quinolines therapeutic use
Structure-Activity Relationship
Antiviral Agents chemical synthesis
Quinolines chemical synthesis
Subjects
Details
- Language :
- English
- ISSN :
- 0022-2623
- Volume :
- 18
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of medicinal chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 1133813
- Full Text :
- https://doi.org/10.1021/jm00237a005