Back to Search
Start Over
The HLA-DPB1--associated component of the IDDM1 and its relationship to the major loci HLA-DQB1, -DQA1, and -DRB1.
- Source :
-
Diabetes [Diabetes] 2001 May; Vol. 50 (5), pp. 1200-5. - Publication Year :
- 2001
-
Abstract
- The major histocompatibility complex (MHC) HLA region on chromosome 6p21 contains the major locus of type 1 diabetes (IDDM1). Common allelic variants at the class II HLA-DRB1, -DQA1, and -DQB1 loci account for the major part of IDDM1. Previous studies suggested that other MHC loci are likely to contribute to IDDM1, but determination of their relative contributions and identities is difficult because of strong linkage disequilibrium between MHC loci. One prime candidate is the polymorphic HLA-DPB1 locus, which (with the DPA1 locus) encodes the third class II antigen-presenting molecule. However, the results obtained in previous studies appear to be contradictory. Therefore, we have analyzed 408 white European families (200 from Sardinia and 208 from the U.K.) using a combination of association tests designed to directly compare the effect of DPB1 variation on the relative predisposition of DR-DQ haplotypes, taking into account linkage disequilibrium between DPB1 and the DRB1, DQA1, and DQB1 loci. In these populations, the overall contribution of DPB1 to IDDM1 is small. The main component of the DPB1 contribution to IDDM1 in these populations appears to be the protection associated with DPB1*0402 on DR4-negative haplotypes. We suggest that the HLA-DP molecule itself contributes to IDDM1.
- Subjects :
- Alleles
Chromosome Mapping
Confidence Intervals
Genetic Predisposition to Disease genetics
Genetic Variation
HLA-DP beta-Chains
HLA-DQ alpha-Chains
HLA-DQ beta-Chains
HLA-DRB1 Chains
Haplotypes
Humans
Italy
United Kingdom
Chromosomes, Human, Pair 6
Diabetes Mellitus, Type 1 genetics
Diabetes Mellitus, Type 1 immunology
HLA-DP Antigens genetics
HLA-DQ Antigens genetics
HLA-DR Antigens genetics
Subjects
Details
- Language :
- English
- ISSN :
- 0012-1797
- Volume :
- 50
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Diabetes
- Publication Type :
- Academic Journal
- Accession number :
- 11334427
- Full Text :
- https://doi.org/10.2337/diabetes.50.5.1200