Back to Search
Start Over
Persistence of Plasmodium falciparum in the placenta after apparently effective quinidine/clindamycin therapy.
- Source :
-
Journal of perinatology : official journal of the California Perinatal Association [J Perinatol] 2001 Mar; Vol. 21 (2), pp. 128-30. - Publication Year :
- 2001
-
Abstract
- The persistence of Plasmodium falciparum in the placenta after apparently adequate therapy with quinine has been described. We describe this phenomenon in the placenta of a 19-year-old woman with falciparum malaria, who was treated with a combination of quinidine and clindamycin. Although this therapy was effective and diminished her peripheral blood parasitemia from 3% at presentation to almost undetectable at the time of delivery, vast numbers of P. falciparum-infected erythrocytes were present in the maternal sinusoids of the placenta. This sequestration of infected erythrocytes produced a local parasitemia in the placenta of 70% to 80%. Additionally, rare Plasmodium-infected erythrocytes were also seen in the fetal blood of the placenta. We review malaria in pregnancy, parasitic involvement of the placenta and emphasize that Plasmodium-infected erythrocytes may persist in the placenta even after clearance of parasites from the peripheral blood.
- Subjects :
- Adult
Animals
Anti-Bacterial Agents administration & dosage
Anti-Bacterial Agents therapeutic use
Antimalarials administration & dosage
Antimalarials therapeutic use
Clindamycin administration & dosage
Drug Therapy, Combination
Female
Humans
Pregnancy
Quinidine administration & dosage
Clindamycin therapeutic use
Malaria, Falciparum drug therapy
Placenta parasitology
Plasmodium falciparum isolation & purification
Pregnancy Complications, Parasitic drug therapy
Quinidine therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 0743-8346
- Volume :
- 21
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal of perinatology : official journal of the California Perinatal Association
- Publication Type :
- Academic Journal
- Accession number :
- 11324359
- Full Text :
- https://doi.org/10.1038/sj.jp.7200465