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TrkA and TrkC neurotrophin receptor-like proteins in the lizard gut.
- Source :
-
Cell and tissue research [Cell Tissue Res] 2001 Mar; Vol. 303 (3), pp. 345-50. - Publication Year :
- 2001
-
Abstract
- The tyrosine kinase proteins (Trk), encoded by the trk family of proto-oncogenes, mediate, in mammals, the action of neurotrophins, a family of growth factors acting on the development and maintenance of the nervous system. Neurotrophins and their specific receptors, TrkA, TrkB and TrkC, seem to be phylogenetically well preserved but, in reptiles, data regarding the occurrence of Trk-like proteins are very scarce, especially in non-nervous organs. Western blot analysis demonstrated that the lizard gut contains TrkA- and TrkC-like, but not TrkB-like, proteins. Consistently, TrkA- and TrkC-like immunoreactivity were both observed in neurons of the anterior intestine, whereas endocrine cells of the stomach and anterior intestine only displayed TrkA-like immunoreactivity. These results demonstrate for the first time the occurrence of Trk-like proteins in non-neuronal tissues of reptilians and provide further evidence for the evolutionary preservation of the molecular mass and cell distribution of Trk neurotrophin receptor-like proteins in the gut of vertebrates.
- Subjects :
- Animals
Blotting, Western
Enteroendocrine Cells cytology
Enteroendocrine Cells immunology
Female
Immunohistochemistry methods
Intestinal Mucosa cytology
Intestine, Large cytology
Intestine, Small cytology
Lizards anatomy & histology
Male
Nerve Growth Factors metabolism
Neurons immunology
Phylogeny
Protein-Tyrosine Kinases immunology
Receptor Protein-Tyrosine Kinases metabolism
Receptor, Nerve Growth Factor metabolism
Receptor, trkA immunology
Receptor, trkC immunology
Receptors, Nerve Growth Factor analysis
Receptors, Nerve Growth Factor immunology
Stomach cytology
Tissue Distribution
Enteroendocrine Cells metabolism
Gastric Mucosa metabolism
Intestinal Mucosa metabolism
Intestine, Large metabolism
Intestine, Small metabolism
Lizards metabolism
Neurons metabolism
Receptor, trkA analysis
Receptor, trkC analysis
Subjects
Details
- Language :
- English
- ISSN :
- 0302-766X
- Volume :
- 303
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Cell and tissue research
- Publication Type :
- Academic Journal
- Accession number :
- 11320650
- Full Text :
- https://doi.org/10.1007/s004410000342