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National surveillance of HIV-1 subtypes for England and Wales: design, methods, and initial findings.
- Source :
-
Journal of acquired immune deficiency syndromes (1999) [J Acquir Immune Defic Syndr] 2001 Apr 01; Vol. 26 (4), pp. 381-8. - Publication Year :
- 2001
-
Abstract
- The HIV-1 infections detected in an ongoing national unlinked anonymous HIV surveillance program were subtyped and analyzed according to demographic and risk characteristics. Of the 893 anti--HIV-1--positive specimens allocated to an exposure group, 70% could be subtyped. Almost 25% of infections subtyped were non-B, mostly subtypes A, C, and D. Non-B infections were rare in homosexual and bisexual men and in drug injectors. Forty percent of infections in heterosexual men attending genitourinary medicine clinics were non-B subtypes; of these, 25% were subtype A infections and 59% were subtype C infections. For female clinic attendees, 61% were non-B subtype infections, of which 48% were subtype A infections and 42% were subtype C infections. Of the clinic attendees born in the United Kingdom and Europe, 14% of the men and 35% of the women were infected with non-B subtypes. In contrast, 78% of infections in antenatal patients were non-B subtypes, of which 61% were subtype A and 29% were subtype C. Extrapolation to the estimated 29,700 prevalent adult infections in the United Kingdom indicates that approximately 8,100 (27%) such infections are non-B subtypes and that these are found almost entirely in heterosexuals. The findings suggest spread of infection of non-B subtypes to heterosexuals born in the United Kingdom from individuals infected in regions of high prevalence.
- Subjects :
- Acute Disease
Adult
Algorithms
England epidemiology
Female
Genotype
HIV Infections complications
HIV-1 genetics
Humans
Male
RNA, Viral analysis
Risk Factors
Serotyping
Sexuality
Sexually Transmitted Diseases complications
Sexually Transmitted Diseases virology
Substance Abuse, Intravenous complications
Substance Abuse, Intravenous virology
Wales epidemiology
HIV Infections epidemiology
HIV Infections virology
HIV-1 classification
Subjects
Details
- Language :
- English
- ISSN :
- 1525-4135
- Volume :
- 26
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Journal of acquired immune deficiency syndromes (1999)
- Publication Type :
- Academic Journal
- Accession number :
- 11317083
- Full Text :
- https://doi.org/10.1097/00126334-200104010-00017